Li-pyrogens, tse tsejoang hape e le endotoxins, li hlahisoa leboteng la extracellular la baktheria ea Gram-negative, ke hore, likaroloana tsa litopo tsa baktheria.Ke ntho ea lipopolysaccharide e nang le boima ba molek'hule ho tloha ho likete tse 'maloa ho isa ho makholo a' maloa a likete, ho itšetlehile ka mefuta ea libaktheria tse e hlahisang.Motsoakong oa metsi, boima ba eona ba limolek'hule bo ka fapana ho tloha ho likete tse makholo ho ea ho limilione
Haeba ho na le palo e nyenyane ea pyrogen e kopantsoeng le moriana 'me ea kenngoa tsamaisong ea mali ea motho, e ka baka feberu e matla esita le lefu.Ka hona, ho bohlokoa haholo ho fokotsa litaba tsa pyrogen mokelikeli oa moriana ka hohle kamoo ho ka khonehang, haholo ha tekanyetso ea ente (joalo ka infusion e kholo) e le kholo, tlhoko ea mahloriso ea pyrogen e lokela ho ba thata le ho feta.
Depyrogenation ea mokelikeli oa ente (kapa metsi a ente) ke sehokelo sa mantlha sa tlhahiso indastering ea meriana ho etsa hore e kopane le melao ea tlhahlobo ea Pharmacopoeia.Hajoale, mekhoa ea depyrogenation hangata e hlahisoa ka mekhahlelo e 3 e latelang:
1. Mokhoa oa distillation o hlahisa metsi a depyrogenated, a sebelisoang e le metsi bakeng sa ente, metsi a ho hlatsoa, joalo-joalo, empa theko ea eona e phahame.
2. Depyrogenation ka mokhoa oa adsorption.E 'ngoe ea litsela ke hore adsorbent ea holim'a metsi e hlahisa lintho tsa pyrogenic mme e lumella lihlahisoa tsa lihlahisoa hore li fete.Tsela ea bobeli ke hore adsorbent adsorbs thepa ea sehlahisoa mme e lumella pyrogen hore e phalle ka ntle.
3. Mokhoa oa karohano ea li-membrane bakeng sa ho tlosoa ha pyrogen e le mokhoa o mocha le theknoloji e ncha e ntse e tsebahala le ho sebelisoa indastering ea meriana.Molao-motheo oa ultrafiltration ho tlosa pyrogen ke ho sebelisa lesela la ultrafiltration le lenyenyane ho feta boima ba molek'hule ea pyrogen ho thibela pyrogen.Mokhoa ona o netefalitsoe.'Me e na le melemo ea matla a tlase a basebetsi, lihlahisoa tse phahameng tsa lihlahisoa le boleng bo botle ba sehlahisoa.
Nako ea poso: Apr-20-2022